NAKED SIBERIAN MOUSE SKIN

The NMR has evolutionarily developed a variety of adaptations that may contribute to its longevity and cancer resistance. The unique feature of the NMR is its protection from cancer, with spontaneous tumors being extremely rare. According to this estimation, the lifespan of the NMR is almost ten times longer than the lifespan of the similarly sized rodent species Mus musculus (M. One of them is the comparison of the size and the lifespan across different animals. There are several ways of comparing longevity between various organisms and species. glaber), or the naked mole rat (NMR), is the longest-living rodent with a maximum lifespan of 32 years. Taken together, this study provides new insights into the mechanisms of cell death in NMR expanding our understanding of longevity, and it paves the way towards the development of innovative therapeutic approaches. Strikingly, our results revealed that NMR cells also exhibit a limited apoptotic response and seem to undergo regulated necrosis.

NAKED SIBERIAN MOUSE SKIN

Skin fibroblasts from Heterocephalus glaber were found to be more resistant to the action of DNA damaging agents compared to fibroblasts from Mus musculus. The effects of methyl methanesulfonate, 5-fluorouracil, and etoposide in both cell types were examined using contemporary cell death analyses. In this study, DNA damage-induced cell death in NMR fibroblasts was investigated in comparison to RCD in fibroblasts from Mus musculus. RCD is a mechanism restricting the proliferation of damaged or premalignant cells, which counteracts aging and oncotransformation. However, the role of regulated cell death (RCD) in the longevity and the protection from cancer in the NMR is still largely unknown. The molecular basis for these unique phenotypic traits of the NMR is under extensive research. The naked mole rat (NMR), Heterocephalus glaber, is the longest-living rodent species, and is extraordinarily resistant to cancer and aging-related diseases.

Naked siberian mouse